The battle of the west promises to be a cracker with Parramatta and Penrith both still unbeaten.
The Eels notched their fourth win in dramatic fashion against Manly last round to build upon their premiership credentials.
For the Panthers, a 26-0 drubbing of the Warriors would have added to their confidence after they drew with Newcastle the week prior.
A host of topline individual clashes are sure to have fans on the edges of their seats.
Eels: Parramatta will start 1-17 after Brad Takairangi and Oregon Kaufusi were the two players to drop out an hour before the match. Nathan Brown returns at lock, bumping Marata Niukore to the bench. Ray Stone joins the interchange with Brad Takairangi and Oregon Kaufusi dropping out. George Jennings and Will Smith were omitted from the reserves list 24 hours before kick-off. The Eels are aiming for their first 5-0 start since 1986.
Panthers: Penrith will start 1-17 after Mitch Kenny and Billy Burns were omitted 60 minutes before kick-off. Dylan Edwards won't be rushed back for Friday night's Battle of the West against Parramatta. Nathan Cleary's return in the halves means Matt Burton moves back to the bench. Jack Hetherington and Edwards were the players cut from the extended bench on Thursday night. Panthers captain James Tamou will play his 250th NRL game.
Eels halfback Mitchell Moses was lauded for his composure as he steered the team to a 19-16 win over Manly, his name even being tossed into Origin selection discussions by some pundits and fans. Nathan Cleary has been NSW's regular No.7 in recent years and he'll want to prove he's still the state's premier playmaker.