There can be few more intimidating places to go in search of a first-up win than CommBank Stadium on a Sunday afternoon.
Faced not only with a powerful Parramatta side but also the raucous blue and gold army, the Titans will need to remain composed and turn to their leaders Kevin Proctor, David Fifita and Isaac Liu to guide them through.
With Mitch Moses and Dylan Brown looking sharp, and Junior Paulo and Reagan Campbell-Gillard ready to rumble, the Eels have the ammunition to take down any rival and they'll be supremely confident of launching their season with a win, just as they have done in four of the past five years.
The Titans have a new captain in Tino Fa'asuamaleaui, a new enforcer in Isaac Liu, a new halves pairing and no shortage of motivation after a heartbreaking loss to the Roosters in last year's elimination final.
Such are the vagaries of the draw that these two sides meet again in round five on the Gold Coast so if the Titans can find a way to spring an upset on Sunday they will carry huge momentum into the return clash which comes after clashes with the Warriors, Raiders and Wests Tigers.
Sportsbet Betting preview: Eels v Titans
Eels: No late changes for the Eels on game day.
Brad Arthur has named the same 17-man squad which was so impressive against premiers Penrith in the trials. Such is Parramatta's depth that quality first-graders Nathan Brown, Mitch Rein and Bryce Cartwright were listed among the reserves for the season opener.
Cartwright is 18th man.
Titans: A late change for the Titans with AJ Brimson dropping out and his place at five-eighth taken by Will Smith. The new man on the bench is Tanah Boyd.
Former Rooster Isaac Liu brings 203 games of experience into the front row, where he will partner Moeaki Fotuaika. After starting every game last year in the front row Jarrod Wallace could not find a place in the 17.
Esan Marsters is 18th man.
Greg Marzhew came in for Corey Thompson earlier in the week.
Fullback for Eels is number 1 Clinton GuthersonFullback for Titans is number 1 Jayden Campbell
Winger for Eels is number 2 Sean RussellWinger for Titans is number 2 Phillip Sami
Centre for Eels is number 3 Will PenisiniCentre for Titans is number 3 Brian Kelly
Centre for Eels is number 4 Waqa BlakeCentre for Titans is number 4 Patrick Herbert
Winger for Eels is number 5 Bailey SimonssonWinger for Titans is number 24 Greg Marzhew
Five-Eighth for Eels is number 6 Dylan BrownFive-Eighth for Titans is number 14 Will Smith
Halfback for Eels is number 7 Mitchell MosesHalfback for Titans is number 7 Toby Sexton
Prop for Eels is number 8 Reagan Campbell-GillardProp for Titans is number 8 Moeaki Fotuaika
Hooker for Eels is number 9 Reed MahoneyHooker for Titans is number 9 Erin Clark
Prop for Eels is number 10 Junior PauloProp for Titans is number 10 Isaac Liu
2nd Row for Eels is number 11 Shaun Lane2nd Row for Titans is number 11 David Fifita
2nd Row for Eels is number 12 Isaiah Papali'i2nd Row for Titans is number 12 Beau Fermor
Lock for Eels is number 13 Ryan MattersonLock for Titans is number 13 Tino Fa'asuamaleaui
Interchange for Eels is number 14 Makahesi MakatoaInterchange for Titans is number 15 Sam Lisone
Interchange for Eels is number 15 Oregon KaufusiInterchange for Titans is number 16 Jaimin Jolliffe
Interchange for Eels is number 16 Ray StoneInterchange for Titans is number 17 Kevin Proctor
Interchange for Eels is number 17 Jake ArthurInterchange for Titans is number 19 Tanah Boyd
Replacement for Eels is number 19 Bryce CartwrightReplacement for Titans is number 21 Esan Marsters
- Referee: Grant Atkins
- Touch Judge: Dave Munro
- Touch Judge: Wyatt Raymond
- Senior Review Official: Matt Noyen
Junior Paulo v Moeaki Fotuaika: Two big men who will be out to mark their turf from the opening exchanges. With the added responsibility of captaincy, Paulo could be even more dangerous, a scary thought when you consider he averaged 128 metres per game in 2021 and was a mainstay of the Blues' Origin-winning pack. Fotuaika was immense for the Titans with 143 metres per game and played all three Origins for the Maroons off the bench.
The Eels have played 31 matches at their state of the art home ground since it was christened in style in 2019 with an Easter Monday thumping of Wests Tigers. Their record at CommBank Stadium stands at an ultra impressive 24 wins and seven losses - a home ground advantage as valuable as any in the NRL.