"Yeah I'm devastated, but it's just not right," he said.
"We tried as much as we could, and did everything we could but it's just not right."
Hayne thinks he won't be back on the football field for another 3-4 weeks, giving his hamstring optimal time to return to full strength.
"[In training we'll] bring it back a couple of gears, probably lower the running and the volume and obviously do a lot of rehab," Hayne said.
"We did everything we could to build it up [to be ready for Origin], but it wasn't ready. It's a tendon injury, so they're a bit tough to handle."
As the most experienced Origin player in the Blues camp, Hayne says he'll still be attending training to give advice to the team.
"I'll be in there are much as I can, to be around the boys and be around training. Later in the week I'll be in there as much as I can be."
Click here to see our interviews with Darcy Lussick and Jake Mullaney in the sheds after last night's match against Manly.